Vol. 53 No. 01 (2003): Volume 53 Number 01, May 2003
Articles

Study of Competitive Protein-Drug Binding by Capillary Electrophoresis

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  • F. Bedia Erim Berker
F. Bedia Erim Berker
Department of Chemistry, Istanbul technical University

Published 05/01/2003

Keywords

  • Capillary electrophoresis,
  • protein,
  • drug,
  • binding constant

How to Cite

Bedia Erim Berker, F. 2003. “Study of Competitive Protein-Drug Binding by Capillary Electrophoresis”. ITU ARI Bulletin of Istanbul Technical University 53 (01):65-69. https://ari.itu.edu.tr/index.php/ituari/article/view/22.

Copyright (c) 2003 ITU Press

Creative Commons License

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Abstract

The competitive affinity of two drugs (the anticoagulant warfarin and the diuretic furosemide) to bovine serum albumin (BSA) is studied by capillary electrophoresis. The competition of these two drugs for the same site on BSA is shown The binding constant between the displacer drug (furosemide) and BSA is estimated relative to the known warfarin—BSA binding constant.
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