Vol. 55 No. sp. is. 1 (2023): Vol. 55, special issue 1, 2023: In memoriam to the late Prof. Dr. Yusuf YAĞCI (1952-2023)
ITU ARI-A Natural Sciences

Hyaluronic Acid-Enriched Pectin-Based Hydrogel Films for Wound Healing: Hyaluronic Acid-Pectin Hydrogels

F. Seniha Güner
Istanbul Technical University

Published 02/03/2024


  • Pectin,
  • Hyaluronic acid,
  • Hydrogel,
  • Wound treatment

How to Cite

Güner Yılmaz, Ö. Zeynep, and F. Seniha Güner. 2024. “Hyaluronic Acid-Enriched Pectin-Based Hydrogel Films for Wound Healing: Hyaluronic Acid-Pectin Hydrogels”. ITU ARI Bulletin of Istanbul Technical University 55 (sp. is. 1):15-22. https://ari.itu.edu.tr/index.php/ituari/article/view/71.


Wound healing research is always looking for approaches to improve patient care. Advanced wound dressings are critical in this process. In this context, the article focuses on the comprehensive examination of the potential of hyaluronic acid-enriched pectin-based hydrogel films to advance wound healing. For comparative analysis, two formulations were prepared: a pectin matrix and a film containing fifty percent hyaluronic acid and pectin. Both formulations were cross-linked using calcium ions. The hydrogels underwent thorough characterization, including Fourier-transform infrared spectroscopy analysis for chemical composition, differential scanning calorimetry for thermal properties determination, and scanning electron microscope imaging for morphological examination of cross-sections. We thoroughly examine their fluid-handling capacities, dehydration rates, and water vapor permeability through meticulous inspection. These characteristics have a significant impact on elasticity, moisture retention, and overall effectiveness throughout the healing process. To demonstrate the transformative potential of HA-enriched pectin-based hydrogel films, we compare their properties to those of pectin hydrogel and a commercial alginate-based wound dressing. As a result, the investigation revealed a notable enhancement in the transparency of the wound dressing, a crucial factor for facilitating continuous monitoring of the wound site without necessitating frequent removal of the dressing. The improvement in water vapor permeability suggests an optimized moisture balance, fostering an environment conducive to efficient wound healing. Moreover, the smoother film contributes to the overall comfort for patients and potentially minimizes skin irritation and discomfort during prolonged wear. The innovative features identified in this study collectively point towards the prospect of these hydrogel films not only as effective wound dressings but also as a step forward in addressing the practical aspects of patient comfort and convenience.


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